Dlx5 and Msx2 regulate mouse anterior neural tube closure through ephrinA5-EphA7
نویسندگان
چکیده
منابع مشابه
Mouse models for neural tube closure defects.
Neural tube closure defects (NTDs), in particular anencephaly and spina bifida, are common human birth defects (1 in 1000), their genetics is complex and their risk is reduced by periconceptional maternal folic acid supplementation. There are > 60 mouse mutants and strains with NTDs, many reported within the past 2 years. Not only are NTD mutations at loci widely heterogeneous in function, but ...
متن کاملNeural Tube Closure in Mouse Whole Embryo Culture
Genetic mouse models are an important tool in the study of mammalian neural tube closure (Gray & Ross, 2009; Ross, 2010). However, the study of mouse embryos in utero is limited by our inability to directly pharmacologically manipulate the embryos in isolation from the effects of maternal metabolism on the reagent of interest. Whether using a small molecule, recombinant protein, or siRNA, del...
متن کاملBiomechanical coupling facilitates spinal neural tube closure in mouse embryos.
Neural tube (NT) formation in the spinal region of the mammalian embryo involves a wave of "zippering" that passes down the elongating spinal axis, uniting the neural fold tips in the dorsal midline. Failure of this closure process leads to open spina bifida, a common cause of severe neurologic disability in humans. Here, we combined a tissue-level strain-mapping workflow with laser ablation of...
متن کاملNeural tube closure in Xenopus
Neurulation is the process by which progenitors of the central nervous system are shaped, separated from and brought beneath the epidermis. The cellular basis of these movements have been investigated in amphibians (Jacobson, 1981; Jacobson and Gordon, 1976; Keller et al., 1992b), chicken (Schoenwolf and Smith, 1990b; Smith and Schoenwolf, 1997) and mice (Bush et al., 1990; Sausedo and Schoenwo...
متن کاملDistinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure.
Early in the development of the central nervous system, progenitor cells undergo a shape change, called apical constriction, that triggers the neural plate to form a tubular structure. How apical constriction in the neural plate is controlled and how it contributes to tissue morphogenesis are not fully understood. In this study, we show that intracellular calcium ions (Ca2+) are required for Xe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2013
ISSN: 0012-1592
DOI: 10.1111/dgd.12044